Pathophysiology of hyperhidrosis

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Hyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins

Clinical features, anatomy and physiology of hyperhidrosis are presented with a review of the world literature on treatment. Level of drug efficacy is defined according to the guidelines of the American Academy of Neurology. Topical agents (glycopyrrolate and methylsulfate) are evidence level B (probably effective). Oral agents (oxybutynin and methantheline bromide) are also level B. In a total...

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Hyperhidrosis

OBJECTIVE The treatment of hyperhidrosis, generalized or focal is a challenge for both physicians and surgeons. Focal hyperhidrosis--axillary, palmar, plantar, craniofacial--is the most common. Generalized hyperhidrosis is usually secondary to a systemic disorder or may be simply drug induced. Focal hyperhidrosis has its onset in childhood or adolescence and has a dramatic effect on one's quali...

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Treatment of severe axillary hyperhidrosis (HH) is limited to a few approved options. Botulinum toxin-A (BTX-A) injections provide temporary, albeit effective reduction in axillary sweating. Several surgical techniques have been used effectively for many years, but the invasiveness, down time, and adverse effects of such procedures are not ideal. Recently, the US Food and Drug Administration (F...

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Primary hyperhidrosis (HH), a condition of sweating in excess of thermoregulatory requirements, affects nearly 3% of the US population and carries significant emotional and psychosocial implications. Unlike secondary HH, primary HH is not associated with an identifiable underlying pathology. Our limited understanding of the precise pathophysiologic mechanism for HH makes its treatment particula...

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ژورنال

عنوان ژورنال: Shanghai Chest

سال: 2019

ISSN: 2521-3768

DOI: 10.21037/shc.2019.07.06